Studies have shown that certain types of oral bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are more prevalent in patients with oral cancers than in those without the disease. These bacteria have been shown to promote inflammation and damage to the cells in the oral cavity, which can lead to the development of cancer.
While the exact mechanisms behind the connection between the oral microbiome and oral cancers are not yet fully understood, there is growing evidence to suggest that maintaining a healthy balance of oral bacteria through proper oral hygiene. Regular dental checkups and oral cancer screenings performed by your dental provider can help to detect oral cancers early, when they are more easily treatable. If you have any concerns about your oral health or notice any changes in your mouth, it's important to schedule an appointment with your dentist or healthcare provider right away.
An oral cancer screening, also known as a head and neck examination, is a simple and painless procedure that is used to detect any signs of oral cancer or precancerous conditions in the mouth and throat. During an oral cancer screening, your dentist or healthcare provider will examine your mouth and throat for any abnormal lumps, bumps, or discolorations. They will also check the soft tissues in your mouth, such as the tongue, gums, cheeks, and lips, as well as the lymph nodes in your neck.
The screening may also involve a visual examination of your oral cavity using specialized equipment, such as a handheld light or mirror, to help your dentist or healthcare provider get a better view of any areas of concern. If any abnormalities are detected during the screening, your dentist or healthcare provider may recommend further testing, such as a biopsy or imaging tests, to determine the cause of the abnormality and whether or not it is cancerous.
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is commonly associated with periodontal disease, which is a severe form of gum disease, which is characterized by inflammation, destruction of gum tissue, and eventual loss of teeth if left untreated.
P. gingivalis is a rod-shaped bacterium that forms biofilms, which are complex communities of bacteria that adhere to surfaces, including teeth and gum tissue. This bacterium has the ability to evade the immune system and can produce a variety of virulence factors that contribute to its pathogenicity. Some of the virulence factors produced by P. gingivalis include enzymes that degrade gum tissue, toxins that damage host cells, and molecules that modulate the host immune response.
Research has shown that P. gingivalis is not only associated with oral health problems but also has been implicated in systemic health issues. Studies have suggested that P. gingivalis may be involved in the development of various systemic conditions, including cardiovascular disease due to its ability to enter the bloodstream from the oral cavity and spread to other parts of the body.
In particular, P. gingivalis has been linked to an increased risk of cardiovascular disease by promoting inflammation, contributing to the formation of atherosclerotic plaques (fatty deposits) in arteries, and interfering with blood clotting mechanisms. Additionally, P. gingivalis has been found in atherosclerotic plaques in arteries, indicating a potential role in the development and progression of cardiovascular disease.
Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that is commonly found in the human oral cavity and gastrointestinal tract. It is a pathogenic bacterium associated with various oral and systemic diseases, including periodontal disease colorectal cancer, and intra-abdominal infections.
Fusobacterium nucleatum is known for its ability to adhere to and invade host cells, which contributes to its pathogenicity. It can also form biofilms, which are complex communities of bacteria that are attached to surfaces and can be difficult to remove. F. nucleatum is considered a "bridge organism" that can facilitate the colonization and growth of other pathogenic bacteria in the oral cavity, contributing to the development of periodontal disease.
In addition to its role in oral health, F. nucleatum has been implicated in systemic diseases, particularly colorectal cancer. Studies have shown that F. nucleatum can be detected in higher levels in colorectal cancer tissues compared to normal tissues, and it is thought to play a role in promoting inflammation and tumor progression. However, the exact mechanisms by which F. nucleatum contributes to colorectal cancer development are still being investigated.
At Dentulu, we are committed to helping our patients maintain optimal oral health and prevent the development of oral cancers. We offer a range of services, including oral cancer screenings and salivary testing for the oral microbiome, to help identify and address any potential risk factors. Our licensed dentists can also provide personalized recommendations for oral hygiene and lifestyle changes to promote a healthy oral microbiome and reduce the risk of oral cancers.
Generally, a salivary testing report will include the patient's identifying factors such as age, name, gender, and the date of the test. Next it will identify the testing results which could include inflammatory markers, oxidative stress markers, and genetic markers. Finally it will include a section on interpreting your results.
At Dentulu, we highly recommend each patient to schedule an appointment with their general dentist or primary care physician, or one of our highly trained Dentulu Teledentists who can discuss with you and assess your current dental and health conditions as well as prior health history to come up with the most appropriate care plan for your needs.
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Once your test results come in, you can interpret the results yourself, follow up with your regular dentist, or schedule a consultation with one of our Dentulu Teledentists from your computer or mobile device at any time that is convenient for you!
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